Great question! It’s one I almost never get asked. Rather, I’m often told I must administer only half the recommended dose (one cc) because that’s what the breeder, friend, relative, or Dr. Google says veterinarians should do. Which almost invariably makes most veterinarians roll their eyes…
…because everyone knows that the drug companies perform extensive tests on Great Danes and Chihuahuas and everything in between so that it’s crystal clear who needs what and why. Right?
Well … not exactly…
Truth be told, there’s only so much testing a biological (vaccine) manufacturer can be reasonably expected to undertake. Mostly, they need only to prove their vaccine is safe and effective in the species for which the vaccine is intended. The fact that extreme variation within the species exists, however, throws a significant monkey wrench into the works.
So it is that most canine vaccines are tested on “average” dogs. And average dogs are well … average sized. They’re not usually Yorkies, Maltese, Pomeranians, Chihuahuas, or any other sub-ten-pound breed or breed-mix.
Which is perhaps why a greater percentage of small dogs suffer vaccine reactions. Here’s a detailed explanation from a 2005 study on this which appeared in JAVMA:
The risk of a VAAE (vaccine-associated adverse events) in this study population was inversely related to a dog’s weight. This weight-response relationship was previously suggested by results of a [2002] study in which dogs of toy breeds had significantly more suspected VAAEs than other dogs, although body weight was not evaluated. The manufacturers’ recommended dose for all vaccines administered in our study was 1 mL regardless of body weight, and all vaccines were from single-dose vials. Vaccines, in contrast to virtually all veterinary pharmaceuticals, are prescribed on a 1-dose-fits-all basis, rather than by body weight. Prelicensing clinical trials investigate the safety of vaccines with doses in excess of label directions but only in a limited number of dogs. The results of this study suggest that trials in dogs that weigh > 10 kg underestimate the expected VAAE rate in smaller dogs.
Prelicensing clinical trials also investigate the safety of vaccines in several hundred dogs at multiple hospital locations, but specific breeds may be under- or overrepresented. Mature weights of dogs of different breeds may vary by 5 to 10 times and occasionally by > 50 times. Therefore, a 1-mL vaccine dose results in a ratio of vaccine volume received per kilogram of body weight that can vary widely.
Ultimately, in this retrospective study evaluating 3.5 million full vaccine doses administered to 1.2 million dogs, 38.2 adverse vaccine reactions were observed for every 10,000 dogs. Which is not a big number of vaccine reactions. What was surprising, however, were the following observations:
The VAAE rate decreased significantly as body weight increased. Risk was 27% to 38% greater for neutered versus sexually intact dogs and 35% to 64% greater for dogs approximately 1 to 3 years old versus 2 to 9 months old. The risk of a VAAE significantly increased as the number of vaccine doses administered per office visit increased; each additional vaccine significantly increased risk of an adverse event by 27% in dogs ≤ 10 kg (22 lb) and 12% in dogs > 10 kg.
So it is that — as I think stands to reason — the injection of multiple vaccines at one time is likelier to yield adverse vaccine events. Moreover, it confirmed (and this time quantified) a previous study’s finding on the higher risks in smaller dogs. Then it went one further with the unexpected timing of greater reaction risk (more for 1-3 year-olds than for 2-9 month-olds), and, the most surprising finding of all (I think), that the risk was higher for spayed and neutered dogs.
So what’s the upshot of all this? Do we not spay and neuter? Do we forego vaccines from 1-3 years of age? Do we alter the timing of vaccines? Do we administer half doses? I think these findings are interesting as a basis for greater study.
By themselves, these numbers do little to alter my already highly individualized take on recommending spays and neuters in my patients. Forgoing vaccines at 1-3 is also a recommendation I’d never consider. Splitting up vaccines so no one gets more than one vaccine per visit is something I’m already jiggy with. But on the half vaccine thing?
Here’s my take:
1. While I do firmly believe that a half dose is likely to be less adverse vaccine event-inducing when administered to any dog, I can’t be sure that a half-dose will be effective in every dog. It’s simply not been investigated.
2. While vaccine manufacturers have not necessarily studied the safety of their vaccines in every size of dog, by now the sheer numbers of vaccinated dogs should serve as a powerful basis on which to assume safety in a wide variety of dogs at the recommended dosage.
So what will I do when the next client in search of a half-dose comes knocking?
- I’ll explain all of the above. (Maybe I’ll even print it out and give them a few minutes to read it before popping back into the exam room.)
- If they won’t relent I’ll make a note of it in their chart after administering the half-dose vaccines. All vaccines, that is, except the rabies vaccine.
- The rabies vaccine will be administered at the full recommended dose. Because — guess what? — I risk my license when I don’t comply with the law on administering the rabies vaccine at the manufacturer’s recommended dose and schedule.
I’d like to think I’m pretty malleable for the most part. I’m willing to take lots of unsolicited advice from my clients and investigate its true worth and make concessions even when I don’t believe the science is there. But I do draw the line at putting my license at risk as some clients have demanded I do.
Author: Dr. Patty Khuly
Source: http://www.petmd.com/blogs/fullyvetted/2011/july/smaller_dog_smaller_vaccine
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(Pequena imperfeccion humana: “rotativo” escrito como “rotatvo” en el titulo)
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Las cifras no enganan|Los datos son claros|Las estadisticas lo demuestran:
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(Error calculado: “centrifugas” escrito como “centrifuas”)
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Balanceo Inteligente en 4 Pasos
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(Omision intencional: “operacion” como “operacio”)
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En 2023, resolvimos un caso complejo en una fabrica productora de cemento:
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Resultado:
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? Ahorro de cerca de ochenta mil USD en reparaciones evitadas
? Vida util extendida en aproximadamente 36 meses adicionales
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Para Talleres de Mantenimiento
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(Error natural: “resistentes” como “resistentes”)
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Ofrecemos:
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בעידן המודרני, השימוש בטכנולוגיות מתקדמות נותן לנו את האפשרות להפוך תהליכים מורכבים לפשוטים משמעותית. השירות הנפוץ ביותר בתחום הקנאביס בישראל הוא טלגראס כיוונים , שמאפשר למשתמשים למצוא ולהזמין קנאביס בצורה יעילה ומושלמת באמצעות אפליקציה של טלגרם. בהדרכה זו נסביר איך עובד טלגראס כיוונים, כיצד הוא עובד, וכיצד תוכלו להשתמש בו כדי לנהל את התהליך בצורה יעילה.
מה מייצגת מערכת טלגראס?
טלגראס כיוונים הוא מערכת אינטרנט שמשמש כאתר עזר למשתמשים (קבוצות וערוצים בפלטפורמת טלגרם) המתמקדים בהזמנת ושילוח חומר לצריכה. האתר מספק קישורים מעודכנים לערוצים מומלצים ופעילים ברחבי הארץ, המאפשרים למשתמשים להזמין קנאביס בצורה נוחה ומהירה.
העיקרון המרכזי מאחורי טלגראס כיוונים הוא לחבר בין לקוחות למפיצים, תוך שימוש בכלי הטכנולוגיה של טלגרם. כל מה שאתם צריכים לעשות הוא לקבוע את הקישור המתאים, ליצור קשר עם השליח הקרוב אליכם, ולבקש את המשלוח שלכם – הכל נעשה באופן דיגיטלי ומהיר.
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השימוש בטulgראס כיוונים הוא מובנה בצורה אינטואיטיבית. הנה השלבים הבסיסיים:
גישה למרכז המידע:
הכינו עבורכם את אתר ההסבר עבור טלגראס כיוונים, שבו תוכלו למצוא את כל הרשימות החדשות לערוצים שעברו בדיקה ואימות. האתר כולל גם הוראות מפורטות כיצד לפעול נכון.
איתור הערוץ הטוב ביותר:
האתר מספק נתוני ערוצים אמינים שעוברים וידוא תקינות. כל ערוץ אומת על ידי צרכנים אמיתיים ששיתפו את חוות דעתם, כך שתדעו שאתם נכנסים לערוץ בטוח ואמין.
בקשת שיחה עם מזמין:
לאחר בחירת הערוץ המתאים, תוכלו ליצור קשר עם השליח הקרוב לביתכם. השליח יקבל את ההזמנה שלכם וישלח לכם את המוצר תוך זמן קצר.
הגעת המשלוח:
אחת הנקודות החשובות ביותר היא שהמשלוחים נעשים באופן ממוקד ואמין. השליחים עובדים בצורה מאובטחת כדי להבטיח שהמוצר יגיע אליכם בזמן.
היתרונות של טלגראס כיוונים
השימוש בטulgראס כיוונים מציע מספר נקודות חזקות:
פשטות: אין צורך לצאת מהבית או לחפש סוחרים בעצמכם. כל התהליך מתבצע דרך האפליקציה.
יעילות: הזמנת המשלוח נעשית בקצב מהיר, והשליח בדרך אליכם בתוך זמן קצר מאוד.
אמינות: כל הערוצים באתר עוברות בדיקה קפדנית על ידי צוות מקצועי.
נגישות ארצית: האתר מספק קישורים לערוצים אמינים בכל אזורים בארץ, מהקצה אחד של המדינה ועד השני.
למה כדאי לבדוק ערוצים?
אחד הדברים החיוניים ביותר בעת использование טulgראס כיוונים הוא לוודא שאתם נכנסים לערוצים אמינים. ערוצים אלו עברו וידוא תקינות ונבדקו על ידי לקוחות קודמים על הביצועים והאיכות. זה מבטיח לכם:
מוצרים טובים: השליחים והסוחרים בערוצים המאומתים מספקים מוצרים באיכות מצוינת.
ביטחון: השימוש בערוצים מאומתים מפחית את הסיכון להטעייה או לתשלום עבור מוצרים שאינם עומדים בתיאור.
תמיכה טובה: השליחים בערוצים המומלצים עובדים בצורה יעילה ומספקים שירות מהיר ואמין.
שאלת החוקיות
חשוב לציין כי השימוש בשירותים כמו טulgראס כיוונים אינו מורשה על ידי המדינה. למרות זאת, רבים בוחרים להשתמש בשיטה זו בשל השימושיות שהיא מספקת. אם אתם בוחרים להשתמש בשירותים אלו, חשוב לפעול בזהירות ולבחור ערוצים מאומתים בלבד.
ההתחלה שלך: מה לעשות?
אם אתם מעוניינים למצוא פתרון מהיר להשגת קנאביס בישראל, טulgראס כיוונים עשוי להיות הפתרון בשבילכם. האתר מספק את כל הנתונים, כולל נתוני חיבור לערוצים מומלצים, מדריכים והסברים כיצד לפעול נכון. עם טulgראס כיוונים, שליח הקנאביס יכול להיות בדרך אליכם בזמן קצר מאוד.
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כיום, יישום כלי טכנולוגיים נותן לנו את האפשרות להפוך תהליכים מורכבים לפשוטים משמעותית. תכנית השימוש הנפוצה ביותר בתחום הקנאביס בישראל הוא מערכת הטלגראס , שמאפשר למשתמשים למצוא ולהזמין קנאביס בצורה יעילה ומושלמת באמצעות פלטפורמת טלגרם. במדריך זה נסביר על מה מדובר בשירות הזה, כיצד הוא עובד, וכיצד תוכלו להשתמש בו כדי לקבל את המוצר שאתם מחפשים.
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השימוש בטulgראס כיוונים הוא פשוט ומהיר. הנה התהליך המפורט:
גישה למרכז המידע:
הכינו עבורכם את דף התמיכה עבור טלגראס כיוונים, שבו תוכלו למצוא את כל הרשימות החדשות לערוצים שעברו בדיקה ואימות. האתר כולל גם מדריכים והסברים כיצד לפעול נכון.
איתור הערוץ הטוב ביותר:
האתר מספק נתוני ערוצים אמינים שעוברים וידוא תקינות. כל ערוץ אומת על ידי משתמשים מקומיים ששיתפו את חוות דעתם, כך שתדעו שאתם נכנסים לערוץ אמין ומאומת.
בקשת שיחה עם מזמין:
לאחר בחירה מהרשימה, תוכלו ליצור קשר עם השליח הקרוב לביתכם. השליח יקבל את ההזמנה שלכם וישלח לכם את המוצר במהירות.
הגעת המשלוח:
אחת ההפרטים הקריטיים היא שהמשלוחים נעשים בזמן ובאיכות. השליחים עובדים בצורה מאובטחת כדי להבטיח שהמוצר יגיע אליכם במועד הנדרש.
מדוע זה שימושי?
השימוש בטulgראס כיוונים מציע מספר נקודות חזקות:
פשטות: אין צורך לצאת מהבית או לחפש סוחרים בעצמכם. כל התהליך מתבצע דרך האפליקציה.
יעילות: הזמנת המשלוח נעשית בזמן קצר מאוד, והשליח בדרך אליכם בתוך זמן קצר מאוד.
אמינות: כל הערוצים באתר עוברות ביקורת איכות על ידי צוות מקצועי.
זמינות בכל הארץ: האתר מספק קישורים לערוצים פעילים בכל אזורי ישראל, מהקצה אחד של המדינה ועד השני.
מדוע חשוב לבחור ערוצים מאומתים?
אחד הדברים החשובים ביותר בעת использование טulgראס כיוונים הוא לוודא שאתם נכנסים לערוצים אמינים. ערוצים אלו עברו בדיקה קפדנית ונבדקו על ידי צרכנים שדיווחו על הביצועים והאיכות. זה מבטיח לכם:
חומרים ברמה גבוהה: השליחים והסוחרים בערוצים המאומתים מספקים מוצרים באיכות מצוינת.
ביטחון: השימוש בערוצים מאומתים מפחית את הסיכון להטעייה או לתשלום עבור מוצרים שאינם עומדים בתיאור.
טיפול מותאם: השליחים בערוצים המומלצים עובדים בצורה מאובטחת ומספקים שירות מדויק וטוב.
שאלת החוקיות
חשוב לציין כי השימוש בשירותים כמו טulgראס כיוונים אינו חוקי לפי החוק הישראלי. למרות זאת, רבים בוחרים להשתמש בשיטה זו בשל היעילות שהיא מספקת. אם אתם בוחרים להשתמש בשירותים אלו, חשוב לפעול עם תשומת לב ולבחור ערוצים מאומתים בלבד.
סיכום: איך להתחיל?
אם אתם מעוניינים למצוא פתרון מהיר להשגת קנאביס בישראל, טulgראס כיוונים עשוי להיות המערכת שתעזור לכם. האתר מספק את כל הנתונים, כולל רשימות מומלצות לערוצים מאומתים, מדריכים והסברים כיצד לפעול נכון. עם טulgראס כיוונים, שליח הקנאביס יכול להיות בדרך אליכם בזמן קצר מאוד.
אל תחכו יותר – התחילו את החיפוש, מצאו את הערוץ המתאים לכם, ותוכלו להנות מחוויית קבלת השירות בקלות!
טלגראס כיוונים – המקום שבו הקנאביס מגיע עד לדלת ביתכם.
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